Targeting of BRAF resistant melanoma via extracellular matrix metalloproteinase inducer receptor
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چکیده
منابع مشابه
CD147 (Extracellular Matrix Metalloproteinase Inducer-EMMPRIN) Expression by Human Articular Chondrocytes
Background: Integrins are a family of transmembrane proteins that allow communication between the extracellular matrix and the interior of cells. Chondrocytes, cells of articular cartilage, express integrins and these molecules appear to have a variety of roles including mechanotransduction. Integrins are known to associate with a number of accessory molecules such as CD147 that may act to regu...
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Introduction: It has been suggested that targeted therapy of growth and immune factors may lead to more effective inhibition of tumor proliferation and recurrence in melanoma cancer. The aim of this study was to investigate the effect of interval training and consumption of Urtica dioica hydroalcoholic extract on Heat shock protein 70 (HSP70) and Extracellular matrix metalloproteinase inducer (...
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Multidrug resistant (MDR) cancer cells overexpressing P-glycoprotein (P-gp) display variations in invasive and metastatic behavior. We previously reported that these properties of MDR cancer cell lines overexpressing P-gp could be altered by chemotherapeutic drugs or MDR modulators (R. S. Kerbel et al., Cancer Surv., 7: 597-629, 1988). To attempt to clarify the mechanism(s) underlying these obs...
متن کاملExtracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease
The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platele...
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BACKGROUND Matrix metalloproteinases (MMPs) are thought to promote progression of atherosclerosis and cardiovascular complications such as plaque rupture. It has been suggested that, on tumor cells, the extracellular MMP inducer (EMMPRIN) is involved in MMP synthesis by as yet unknown mechanisms. On cardiovascular cells, regulation of EMMPRIN in vivo or any functional relevance for MMP inductio...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2014
ISSN: 0022-4804
DOI: 10.1016/j.jss.2014.02.021